"Won't Somebody Help Us Please....
Find a Cure for This Disease?"

Finding the Cure for DM Foundation

A 501(c)3 Non Profit Organization

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        NEW!!  2017 DM CLINICAL TRIAL !   


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We at Finding the Cure for DM, are constantly striving to locate Research Projects or Clinical Trials whose priority is to find a treatment or a cure for Canine Degenerative Myelopathy. FCDMF is committed to donating or Sponsoring these types of programs at minimum, 

on an annual basis.

Under the AWA, research institutions are required to provide an Institutional Animal Care and Use Committee (IACUC) protocol to FCDMF before consideration for grant awards.

If you or your Institution would like to be considered for a grant of this nature, 

please contact us HERE.  

(Please note that due to our small stature, FCDMF does not permit overhead charges to be included in financial awards)

 

FCDMF has been sponsoring project "New Hope", a new, initial research project with the ultimate goal of silencing the gene(s) that contribute to DM symptoms. If successful, we anticipate it will stop further progression of symptoms in its tracks.

Currently, the ONLY funding has been by your donations through Finding the Cure for DM Foundation. We hope you will find it in your heart to continue your generosity, bringing us one step closer to a Cure! Thank you for all you have done to help us initiate this promising research!

4/29/2016 Update :

***** 4/29/2016While the initiation of Project New Hope was aimed at evaluating the possibility of silencing the SOD1 gene, which by many is perceived to be a contributing factor to DM, we have now evaluated a different gene.
Due to the positive preliminary progress report for silencing the cSOD1 gene, we have extended this study to include another gene reputed to have some significance in DM symptoms. The Canine DRB1 gene, also reputed to contribute to the symptoms of Degenerative Myelopathy. WE HAVE VERY POSITIVE RESULTS! Our science team at Silagene has concluded that in vitro, using their U1 Adaptor technology, they have indeed been able to silence the Canine DRB1 gene! This is terrific news, and is a direct reflection of our supporters pulling together for a great cause, so close to all of our hearts! Thank you..one and all, for believing in and continuing to help support this research! However, it does not end here. Project "New Hope" is only in it's infancy stage. We will now be taking steps into finding a Clinical Veterinarian to participate and continue reaching further into this study, in the hopes of eventually leading us into Canine Clinical Trials!
Contrary to the ALS comparison, investigating DRB1 has led scientists to believe that GSDM may be a different “type” of DM, inherently more like PPMS (Primary Progressive MS.)
Targeting this second gene will enhance the ability to bring in DM-expert veterinarians for moving the project forward. Furthermore, being able to target two genes, either alone or together, should greatly broaden the interest to those who want to do clinical trials.
Please see the newest update below, and please consider FCDMF for your charitable contributions to continue to help move these studies forward. 
FDCMF, through your donations, is currently the ONLY funding source for project New Hope. 
We are more than grateful to have you fighting DM beside us! Thank You!!
2/13/2016*****ADDENDUM TO PROJECT "NEW HOPE." 
This addendum for the SOD1 silencing consists of the evaluation of the DLA-DRB1 gene that we would like to extend into project "New Hope."
While the initiation of Project New Hope was aimed at evaluating the possibility of silencing the SOD1 gene, which by many is perceived to be a contributing factor to DM, we would now like to begin evaluating a different gene.
Due to the positive preliminary progress report for silencing the cSOD1 gene, we would like to extend this study to include another gene reputed to have some significance in DM symptoms.
This next portion of the study would revolve around the silencing of the DLA-DRB1 gene. In past studies, related research indicated that DRB1 housed the 1101 allele, also thought to contribute primarily to GSDM.
Contrary to the ALS comparison, investigating DRB1 has led scientists to believe that GSDM may be a different “type” of DM, inherently more like PPMS (Primary Progressive MS.)
Targeting a second gene will enhance the ability to bring in DM-expert veterinarians for moving the project forward. Furthermore, being able to target two genes, either alone or together, should greatly broaden the interest to those who want to do clinical trials.
While the initial study into the feasibility of silencing the SOD1 gene has been funded by previous donations and fundraising events, future studies in this direction will require additional funding.
As well, to initiate research and silencing of the DLA-DRB1 gene, funding will be also required.
To date, the ONLY funding of this project has been with your donations through the Finding the Cure for DM Foundation. We hope you will find it in your heart to continue your generous contributions to this much needed research.
If you would like your donation to go to only the DRB1 portion of this study, please make a note with your contribution, and it will be allocated to DRB1. The same applies to the SOD1 portion of this study.
If there is no preference as to which portion of research your donations go to, no note is required.
We at FCDMF wish to thank all who have contributed to initiate this program, and those who continue to help see it continue.
Please review the attached proposal for the possibility of extending DM research into silencing of the DRB1 gene.
02/13/2016:   RESEARCH UPDATE!! 
We would like to share the preliminary progress of Project New Hope, SOD1 gene silencing.
In this initial in vitro study, Silagene has had very good success in silencing up to 75% of the SOD1 gene, with their patented U1 Adaptor Technology.
This is wonderful news, and offers great potential for continuing this line of research!
It is our hope that with continual funding, it may be possible to continue research and be into canine clinical trials of this procedure within a year.
The attached document outlines the progress of Project New Hope up to this point in time.
We anticipate it will fill your heart with “New Hope,” as it has ours!
Furthermore, due to the positive preliminary results with the SOD1 gene, in a time and money saving opportunity, we would like to move forward with an extension of the current study to another gene reputed to be a possible link to canine DM.
This next portion of the study would revolve around the silencing of the DLA-DRB1 gene, which houses the 1101 allele.
Please anticipate the next announcement which clarifies the purpose of the intended work on the DLA-DRB1 gene.