Finding the Cure for DM Foundation

Get support here from many experienced owners that have or are currently fighting DM with their babies.

• FCDMF Facebook page https://www.facebook.com/www.cure4dm.org/?ref=bookmarks https://www.facebook.com/www.cure4dm.org/?ref=bookmarks "Like " our Facebook page to keep up with the latest activity, research, and information of "Finding the Cure for DM, Inc." (FCDMF)

• Degenerative Myelopathy (DM) awareness group https://www.facebook.com/groups/DMDogs/ https://www.facebook.com/groups/DMDogs/ This group is for anyone who is dealing with or has dealt with a dog who has Degenerative Myelopathy (DM) or anyone who is needing support and help. Here you can vent, ask questions and share experiences with this heartbreaking disease with many others going through DM in their own lives.

• Jack Flash's Home of the DM Support Group www.mzjf.com www.mzjf.com Thank you to Marjorie Zimmerman for allowing us to link her DM support group

• German Shepherds and Degenerative Myelopathy https://www.facebook.com/groups/161471140562457/ https://www.facebook.com/groups/161471140562457/

Supplies and Info for your Handicapped pets

• HELP EM UP HARNESS helpemup.com/store helpemup.com/store Rear body and whole body harnesses and walking aids.

• Walkin Wheels walkinwheels.com/ walkinwheels.com/ Help your companion remain mobile. Walkin Wheels provides carts for your handicapped pets, and is fully adjustable to fit your best friends needs.

• Eddies Wheels eddieswheels.com/ eddieswheels.com/ Eddies wheels offers carts for your disabled pets! Refurbished EW carts, as available, may also be purchased at a discounted price.

• Handicapped Pets www.handicappedpets.com/ www.handicappedpets.com/ Mobility Aids and Equipment for your Handicapped Pets

• NEO-PAWS www.neopaws.com/index.php?cnf=index www.neopaws.com/index.php?cnf=index Pet safety, support and comfort products. Booties, vests and more..

• Pet Step www.petstep.com/ www.petstep.com/ Ramps, kennels & misc. pet supplies

• Solvit Products www.solvitproducts.com/default.aspx www.solvitproducts.com/default.aspx Access, Mobility and Travel aids for your pets.

• Orthopedic Foundation for Animals www.offa.org/ www.offa.org/ To promote the health and welfare of companion animals through a reduction in the incidence of genetic disease. The OFA offers DNA based disease testing through an exclusive license arrangement with the University of Missouri.

• Canine Genetic Diseases Network www.caninegeneticdiseases.net/DM/mainDM.htm www.caninegeneticdiseases.net/DM/mainDM.htm Canine Genetic Diseases Network - DM

• PNAS Report www.pnas.org/content/early/2009/02/02/0812297106.full.pdf www.pnas.org/content/early/2009/02/02/0812297106.full.pdf Genome-wide association analysis reveals a SOD1 mutation in canine degenerative myelopathy that resembles amyotrophic lateral sclerosis

• Degenerative Myelopathy in German Shepherd Dogs wholisticpawsvet.com/articles/Degenerative_Myelopathy_German_Shepherd_Dogs.pdf wholisticpawsvet.com/articles/Degenerative_Myelopathy_German_Shepherd_Dogs.pdf R.M. Clemmons, DVM, PhD Associate Professor of Neurology & Neurosurgery Small Animal Clinical Sciences Copyright University of Florida 1997

• Degenerative Myelopathy Fact Sheet www.gavetrehab.com/files/GVR-Degenerative-Myelopathy-Fact-Sheet.pdf www.gavetrehab.com/files/GVR-Degenerative-Myelopathy-Fact-Sheet.pdf GVR - Georgia Veterinary Rehabilitation Fitness & Pain Management.

• GSDM https://www.facebook.com/photo.php?fbid=106298662876987&set=a.106298659543654.252.103714409802079&type=1&theater https://www.facebook.com/photo.php?fbid=106298662876987&set=a.106298659543654.252.103714409802079&;type=1&theater Dr. Clemmons updated article 2013

• Degenerative Myelopathy in Dogs www.lapoflove.com/diseases/DegenerativeMyelopathy.pdf www.lapoflove.com/diseases/DegenerativeMyelopathy.pdf A brief guide on disease progression including end-of-life symptoms

• Articles Stacey Sullivan DMV www.cure4dm.org/Articles%20DR%20Stacey%20Sullivan,%20DMV.pdf www.cure4dm.org/Articles%20DR%20Stacey%20Sullivan,%20DMV.pdf Articles

research articles are ordered with the most recent publications listed first.

• Variants within the SP110 nuclear body protein modify risk of canine degenerative myelopathy www.pnas.org/content/113/22/E3091.full www.pnas.org/content/113/22/E3091.full latest information. A new gene implicated in the development of DM has been discovered Published 4/15/2016 113 no. 22 > Emma L. Ivansson, E3091???E3100, doi: 10.1073/pnas.1600084113 Variants within the SP110 nuclear body protein modify risk of canine degenerative myelopathy Emma L. Ivanssona,b,1,2, Kate Megquiera,b, Sergey V. Kozyreva, Eva Muréna, Izabella Baranowska Körbergc,3, Ross Swoffordb, Michele Koltookianb, Noriko Tonomurab,d, Rong Zenge, Ana L. Kolicheskie, Liz Hansene, Martin L. Katzf, Gayle C. Johnsone, Gary S. Johnsone, Joan R. Coatesg, and Kerstin Lindblad-Toha,b,1

• Expression of Autophagy-Related Proteins in the Spinal Cord of Pembroke Welsh Corgi Dogs With Canine Degenerative Myelopathy. www.ncbi.nlm.nih.gov/pubmed/25732177 www.ncbi.nlm.nih.gov/pubmed/25732177 Vet Pathol. 2015 Nov;52(6):1099-107. doi: 10.1177/0300985815570070. Epub 2015 Mar 2. Expression of Autophagy-Related Proteins in the Spinal Cord of Pembroke Welsh Corgi Dogs With Canine Degenerative Myelopathy. Ogawa M1, Uchida K2, Yamato O3, Mizukami K3, Chambers JK1, Nakayama H1.

• Canine degenerative myelopathy: a model of human amyotrophic lateral sclerosis. www.ncbi.nlm.nih.gov/pubmed/26432396 www.ncbi.nlm.nih.gov/pubmed/26432396 Zoology (Jena). 2015 Sep 21. pii: S0944-2006(15)00085-9. doi: 10.1016/j.zool.2015.09.003. [Epub ahead of print] Canine degenerative myelopathy: a model of human amyotrophic lateral sclerosis. Nardone R1, H??¶ller Y2, Taylor AC2, Lochner P3, Tezzon F3, Golaszewski S4, Brigo F5, Trinka E2.

• Accumulation and aggregate formation of mutant superoxide dismutase 1 in canine degenerative myelopathy www.ncbi.nlm.nih.gov/pubmed/26162235 www.ncbi.nlm.nih.gov/pubmed/26162235 Accumulation and aggregate formation of mutant superoxide dismutase 1 in canine degenerative myelopathy. Nakamae S1, Kobatake Y1, Suzuki R2, Tsukui T2, Kato S3, Yamato O4, Sakai H1, Urushitani M5, Maeda S1, Kamishina H6. 2015 Sep 10;303:229-40. doi: 10.1016/j.neuroscience.2015.06.066. Epub 2015 Jul 8.

• A retrospective study of the prevalence of the canine degenerative myelopathy associated superoxide dismutase 1 mutation (SOD1:c.118Gâ??>â??A) in a referral population of German Shepherd dogs from the UK. www.ncbi.nlm.nih.gov/pubmed/26401327 www.ncbi.nlm.nih.gov/pubmed/26401327 Canine Genet Epidemiol. 2014 Sep 25;1:10. doi: 10.1186/2052-6687-1-10. eCollection 2014. A retrospective study of the prevalence of the canine degenerative myelopathy associated superoxide dismutase 1 mutation (SOD1:c.118Gâ??>â??A) in a referral population of German Shepherd dogs from the UK. Holder AL1, Price JA1, Adams JP2, Volk HA3, Catchpole B1.

• Quantitative assessment of hsp70, IL-1?????² and TNF-?????± in the spinal cord of dogs with E40K SOD1-associated degenerative myelopathy www.sciencedirect.com/science/article/pii/S1090023314000884 www.sciencedirect.com/science/article/pii/S1090023314000884 The Veterinary Journal Volume 200, Issue 2, May 2014, Pages 312-317 Quantitative assessment of hsp70, IL-1?????² and TNF-?????± in the spinal cord of dogs with E40K SOD1-associated degenerative myelopathy M.C. Lovetta, J.R. Coatesb, Y. Shuc, M.J. Oglesbeec, W. Fennera, S.A. Moored, Corresponding author contact information, E-mail the corresponding author

• The chaperone protein clusterin may serve as a cerebrospinal fluid biomarker for chronic spinal cord disorders in the dog www.ncbi.nlm.nih.gov/m/pubmed/23990410/?i=11&from=degenerative+Myelopathy www.ncbi.nlm.nih.gov/m/pubmed/23990410/?i=11&from=degenerative+Myelopathy Cell Stress Chaperones. 2014 May;19(3):311-20. doi: 10.1007/s12192-013-0457-4. Epub 2013 Aug 29. Affiliation

• Breed Distribution of SOD1 Alleles Previously Associated with Canine Degenerative Myelopathy onlinelibrary.wiley.com/doi/10.1111/jvim.12317/full onlinelibrary.wiley.com/doi/10.1111/jvim.12317/full the latest findings in Canine Degenerative Myelopathy, published February 13, 2014 includes necropsy data

• Degenerative myelopathy in German Shepherd Dog: comparison of two molecular assays for the identification of the SOD1:c.118G>A mutation. www.ncbi.nlm.nih.gov/pubmed/24390315 www.ncbi.nlm.nih.gov/pubmed/24390315 Mol Biol Rep. 2014 Feb;41(2):665-70. doi: 10.1007/s11033-013-2904-9. Epub 2014 Jan 5. Degenerative myelopathy in German Shepherd Dog: comparison of two molecular assays for the identification of the SOD1:c.118G>A mutation. Capucchio MT1, Spalenza V, Biasibetti E, Bottero MT, Rasero R, Dalmasso A, Sacchi P.

• Characterization of thoracic motor and sensory neurons and spinal nerve roots in canine degenerative myelopathy, a potential disease model of amyotrophic lateral sclerosis onlinelibrary.wiley.com/doi/10.1002/jnr.23332/abstract onlinelibrary.wiley.com/doi/10.1002/jnr.23332/abstract Article first published online: 21 DEC 2013

• Characterization of intercostal muscle pathology in canine degenerative myelopathy: A disease model for amyotrophic lateral sclerosis onlinelibrary.wiley.com/doi/10.1002/jnr.23287/abstract onlinelibrary.wiley.com/doi/10.1002/jnr.23287/abstract Article first published online: 16 SEP 2013

• Dr. Clemmons 2013 lecture 1drv.ms/1yQrVEc 1drv.ms/1yQrVEc Thank you to the American Holistic Veterinary Medial Association for supplying this transcript from Dr. Clemmons' 2013 lecture.

• The chaperone protein clusterin may serve as a cerebrospinal fluid biomarker for chronic spinal cord disorders in the dog link.springer.com/article/10.1007%2Fs12192-013-0457-4 link.springer.com/article/10.1007%2Fs12192-013-0457-4 Date: 29 Aug 2013

• Degenerative Myelopathy in a Bernese Mountain Dog with a Novel SOD1 Missense Mutation onlinelibrary.wiley.com/doi/10.1111/j.1939-1676.2011.0760.x/abstract onlinelibrary.wiley.com/doi/10.1111/j.1939-1676.2011.0760.x/abstract Degenerative Myelopathy in a Bernese Mountain Dog with a Novel SOD1 Missense Mutation F.A. Wininger1, R. Zeng2, G.S. Johnson2, M.L. Katz3, G.C. Johnson2, W.W. Bush4, J.M. Jarboe4 and J.R. Coates1 Article first published online: 16 AUG 2011 DOI: 10.1111/j.1939-1676.2011.0760.x

• Detection of oligoclonal bands in cerebrospinal fluid from German Shepherd dogs with degenerative myelopathy by isoelectric focusing and immunofixation. www.ncbi.nlm.nih.gov/pubmed/18533922?dopt=Abstract www.ncbi.nlm.nih.gov/pubmed/18533922?dopt=Abstract Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA 2008 Jun

• Measurement of myelin basic protein in the cerebrospinal fluid of dogs with degenerative myelopathy. www.ncbi.nlm.nih.gov/pubmed/17806078 www.ncbi.nlm.nih.gov/pubmed/17806078 Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA 2007 Sep

• Autologous bone marrow stromal cell transplantation in German Shepherd degenerative myelopathy www.fasebj.org/cgi/content/meeting_abstract/20/5/A1106-b www.fasebj.org/cgi/content/meeting_abstract/20/5/A1106-b (2006) Autologous bone marrow stromal cell transplantation in German Shepherd degenerative myelopathy Roger M. Clemmons , Hiroaki Kamishina , Takashi Oji , Jennifer A. Cheeseman and Gerald J. Demuth Small Animal Clinical Sciences, University of Florida, 2015 SW 16th Avenue, Gainesville, Florida, 32610-0126

• GERMAN SHEPHERD DOG DEGENERATIVE MYELOPATHY: ufdcimages.uflib.ufl.edu/UF/E0/01/58/25/00001/oji_t.pdf ufdcimages.uflib.ufl.edu/UF/E0/01/58/25/00001/oji_t.pdf A thesis written in 2006 by TAKASHI OJI who was receiving hi Master Of Science degree.

• CT myelography of the thoraco-lumbar spine in 8 dogs with degenerative myelopathy. www.ncbi.nlm.nih.gov/pubmed/16293999 www.ncbi.nlm.nih.gov/pubmed/16293999 J Vet Sci. 2005 Dec;6(4):341-8. CT myelography of the thoraco-lumbar spine in 8 dogs with degenerative myelopathy. Jones JC1, Inzana KD, Rossmeisl JH, Bergman RL, Wells T, Butler K.

• Molecular genetic and expression analysis of alpha-tocopherol transfer protein mRNA in German shepherd dogs with degenerative myelopathy. www.ncbi.nlm.nih.gov/pubmed/12592926 www.ncbi.nlm.nih.gov/pubmed/12592926 Berl Munch Tierarztl Wochenschr. 2003 Jan-Feb;116(1-2):31-6. Molecular genetic and expression analysis of alpha-tocopherol transfer protein mRNA in German shepherd dogs with degenerative myelopathy. Fechner H1, Johnston PE, Sharp NJ, Montague P, Griffiths IR, Wang X, Olby N, Looman AC, Poller W, Flegel T.

• Central nervous system pathology in 25 dogs with chronic degenerative radiculomyelopathy veterinaryrecord.bmj.com/content/146/22/629 veterinaryrecord.bmj.com/content/146/22/629 (2000) Central nervous system pathology in 25 dogs with chronic degenerative radiculomyelopathy P. E. J. Johnston, BVM&S, PhD, MRCVS1,1, J. A. Barrie1, M. C. McCulloch1, T. J. Anderson, BVM&S, MVM, PhD, DSAO, MRCVS1 and I. R. Griffiths, BVMS, PhD, FRCVS1

• Immunohistochemical evidence for immunoglobulin and complement deposition in spinal cord lesions in degenerative myelopathy in German shepherd dogs (full article) www.ncbi.nlm.nih.gov/pmc/articles/PMC1263654/pdf/cjvetres00029-0023.pdf www.ncbi.nlm.nih.gov/pmc/articles/PMC1263654/pdf/cjvetres00029-0023.pdf Can J Vet Res. 1994 Jan;58(1):20-4. Immunohistochemical evidence for immunoglobulin and complement deposition in spinal cord lesions in degenerative myelopathy in German shepherd dogs. Barclay KB1, Haines DM.

• Degenerative myelopathy. www.ncbi.nlm.nih.gov/pubmed/1641928 www.ncbi.nlm.nih.gov/pubmed/1641928 Department of Small Animal Clinical Sciences, University of Florida College of Veterinary Medicine, Gainesville 1992 Jul

• Degenerative myelopathy in a German shepherd. www.ncbi.nlm.nih.gov/pubmed/6749121 www.ncbi.nlm.nih.gov/pubmed/6749121 Mod Vet Pract. 1984 Jul;65(7):535-7. Degenerative myelopathy in a German shepherd. Romatowski J.

• Degenerative myelopathy in an adult miniature poodle. www.ncbi.nlm.nih.gov/pubmed/4008305 www.ncbi.nlm.nih.gov/pubmed/4008305 J Am Vet Med Assoc. 1985 Jun 1;186(11):1213-5. Degenerative myelopathy in an adult miniature poodle. Matthews NS, de Lahunta A.

• Degenerative myelopathy in a family of Siberian Husky dogs. www.ncbi.nlm.nih.gov/pubmed/12002594 www.ncbi.nlm.nih.gov/pubmed/12002594 J Am Vet Med Assoc. 1983 Nov 1;183(9):998-1000, 965. Degenerative myelopathy in a family of Siberian Husky dogs. Bichsel P1, Vandevelde M, Lang J, Kull-H??¤chler S.

• Progressive myelopathy in older German shepherd dogs. II. Presence of circulating suppressor cells. www.ncbi.nlm.nih.gov/pubmed/6444648 www.ncbi.nlm.nih.gov/pubmed/6444648 1980 Mar;124(3):1216-22. Progressive myelopathy in older German shepherd dogs. II. Presence of circulating suppressor cells. Waxman FJ, Clemmons RM, Hinrichs DJ.

• Canine Degenerative Myelopathy: A Translational Medicine Approach to Amyotrophic Lateral Sclerosis vimeo.com/42419715 vimeo.com/42419715 Presentation by Joan R. Coates, DVM, MS, University of Missouri Professor of Veterinary Neurology & Neurosurgery at the 2011 National Parent Club Canine Health Conference hosted by the AKC Canine Health Foundation.